STRENGTH

Technology Platform

TCR innovative drug R&D platform

The SMART-TCR affinity optimization platform, a revolutionary TCR affinity optimization technology, has greatly improved the success rate and efficiency of TCR affinity optimization.

Tumor Antigen Identification

  • •Deep mining of Omics data
  • •Established tumor antigen database

T Cell Epitope Identification

  • •Cover all dominant HLA genotype
  • • More than 50 prioritized T cell epitopes under development

Natural TCR Acquisition

  • •High efficient, Low cost single-cell TCR cloning technology
  • •High-capacity Human TCR library
  • •High-throughput & High-content T-cell display platform

SMART-TCR Affinity Optimization

  • •Highly efficient SMART-TCR system based on T-cell display
  • •Affinity optimized TCR screening based on T cell functional assay
  • •Off-target TCRs can be removed by negative selection module

TCR bispecifics development

  • •AI-assisted TCR bispecifics discovery platform
  • •Prioritized new formats with excellent expression performance and potency

TCR Preclinical Study

  • •Allo-reactivity assay based on single HLA cell bank
  • •Specificity evaluation using X-Scan and primary cells killing
  • •In vitro and in vivo antitumor activity
  • •Preclinical safety evaluation
  • •Preclinical Pharmacokinetic (PK) Assays

TCR clinical trial

  • •Advanced TCR-T CMC platform
  • •High quality clinical resources